Ruminant livestock TR V(D)J genes and CDR3 repertoire.

Fengli Wu, Yunlan Deng, Xinsheng Yao, Jun Li

Veterinary immunology and immunopathology 2024 Nov

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Ruminant livestock exhibit certain immune characteristics that make them valuable models for studying T cell receptor diversity and immune responses. This resistance is attributed to their well-developed immune system, comprising both innate and adaptive components. In this review, we delve into the intricate workings of the immune system of ruminant livestock, focusing on innate immunity and adaptive immunity. Specifically, we discuss the TR V(D)J genes (including TRB, TRG, and TRA/D chain) and the characteristics of the complementary determining region 3 (CDR3) repertoire in bovine and ovine species, shedding light on the diversity and functionality of the T-cell receptor(TCR) repertoire in these species. Understanding the distinct features of these germline genes and CDR3 repertoires is essential for unraveling the complexities of immune responses in ruminant livestock. Lastly, we outline future prospects in this field, emphasizing the importance of further research to enhance our understanding of ruminant livestock immunity and its potential applications in disease management, vaccine development, and breeding strategies. Copyright © 2024 Elsevier B.V. All rights reserved.

Citation

Fengli Wu, Yunlan Deng, Xinsheng Yao, Jun Li. Ruminant livestock TR V(D)J genes and CDR3 repertoire. Veterinary immunology and immunopathology. 2024 Nov;277:110829