Aptamer biosensors for thrombin.

Thrombin, a key factor in the coagulation cascade, is a valuable biomarker of great importance for the prognosis, diagnosis, and monitoring of various diseases, including cancer and heart disease. Due to the increasing attention to the development of point-of-care testing (POCT) options, various types of biosensors have been invented to enhance the accuracy and speed of detection of important biomarkers such as thrombin. Implementation of aptamers in biosensors (aptasensors) improves the target recognition capacity due to the high-affinity binding nature of aptamers. Herein, this review presents recent studies of aptasensors for thrombin detection based on different detection mechanisms encompassing optical biosensors, surface-enhanced Raman spectroscopy (SERS), electrochemical detection, piezoelectric detection, and lateral flow assay. Copyright © 2024 Elsevier B.V. All rights reserved.

Citation

Zahra Oushyani Roudsari, Hassan Ghasemi, Seyyed Hossein Khatami, Marjan Khorsand, Fereshteh Rahdan, Davood Chehri, Omid Sheydaei, Saleh Aiiashi, Reza Mahmoudi, Ahmad Movahedpour. Aptamer biosensors for thrombin. Clinica chimica acta; international journal of clinical chemistry. 2025 Jan 15;565:119976

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PMID: 39321910

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