Clear Search sequence regions


  • heparin (7)
  • heparinoid (3)
  • humans (1)
  • research (1)
  • sepsis (3)
  • Sizes of these terms reflect their relevance to your search.

    Systematic inflammatory response syndrome (SIRS) and the accompanying sepsis pose a huge threat to human health worldwide. Heparin is a part of the standard supportive care for the disease. However, the molecular mechanism is not fully understood yet, and the potential signaling pathways that play key roles have not yet been elucidated. In this paper, the main findings regarding the molecular mechanisms associated with the beneficial effects of heparin, including inhibiting HMGB-1-driven inflammation reactions, histone-induced toxicity, thrombo-inflammatory response control and the new emerging mechanisms are concluded. To set up the link between the preclinical research and the clinical effects, the outcomes of the clinical trials are summarized. Then, the structure and function relationship of heparin is discussed. By providing an updated analysis of the above results, the paper highlights the feasibility of heparin as a possible alternative for sepsis prophylaxis and therapy.

    Citation

    Ying Song, Yuxiang Wu, Fangfang Ding, Shuo Li, Yaojia Shen, Bingyan Yang, Xinran Tang, Lige Ren, Lirong Deng, Xuewen Jin, Yishu Yan. The Preventive and Therapeutic Effects of Acute and Severe Inflammatory Disorders with Heparin and Heparinoid. Biomolecules. 2024 Aug 28;14(9)

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 39334845

    View Full Text