Syntaxin 3B: A SNARE Protein Required for Vision.

Himani Dey, Mariajose Perez-Hurtado, Ruth Heidelberger

International journal of molecular sciences 2024 Oct 03

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Syntaxin 3 is a member of a large protein family of syntaxin proteins that mediate fusion between vesicles and their target membranes. Mutations in the ubiquitously expressed syntaxin 3A splice form give rise to a serious gastrointestinal disorder in humans called microvillus inclusion disorder, while mutations that additionally involve syntaxin 3B, a splice form that is expressed primarily in retinal photoreceptors and bipolar cells, additionally give rise to an early onset severe retinal dystrophy. In this review, we discuss recent studies elucidating the roles of syntaxin 3B and the regulation of syntaxin 3B functionality in membrane fusion and neurotransmitter release in the vertebrate retina.

Citation

Himani Dey, Mariajose Perez-Hurtado, Ruth Heidelberger. Syntaxin 3B: A SNARE Protein Required for Vision. International journal of molecular sciences. 2024 Oct 03;25(19)