Balancing acts: The posttranslational modification tightrope of flavivirus replication.

RuthMabel Boytz, Maudry Laurent-Rolle

PLoS pathogens 2024 Oct

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Posttranslational modifications (PTMs) such as phosphorylation, ubiquitination, SUMOylation, and ISGylation are involved in various cellular pathways, including innate immunity and disease processes. Many viruses have developed sophisticated mechanisms to modulate these host PTMs, either by inhibiting the interferon pathway or by enhancing the stability and function of viral proteins essential for replication. In this Pearl, we review the literature on how flaviviruses are impacted by and exploit posttranslational modifications to their advantage. Copyright: © 2024 Boytz, Laurent-Rolle. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Citation

RuthMabel Boytz, Maudry Laurent-Rolle. Balancing acts: The posttranslational modification tightrope of flavivirus replication. PLoS pathogens. 2024 Oct;20(10):e1012626