Sebaceous gland carcinoma of the eyelid co-occurred with other tumors: a report of four cases].

This article reported four cases of sebaceous gland carcinoma of the eyelid with other tumors. Among them, three cases were co-occurred with other ocular tumors, two cases with visceral malignancies, and one case with chronic lymphocytic leukemia/small lymphocytic lymphoma. Immunohistochemistry and/or whole-exome sequencing confirmed that the two cases with visceral malignancies did not meet the criteria for Muir-Torre syndrome. Additionally, whole-exome sequencing was performed on two cases of sebaceous gland carcinoma of the eyelid, both revealing mutations in the ZNF750 gene. Surgical interventions included excision of the eyelid tumors in three cases and enucleation of orbital tissues and eye removal in one case. Follow-up results showed no recurrence in two cases with eyelid tumors and one case with orbital invasion, while one patient died due to peritoneal metastasis from ovarian cancer.

Citation

Y C Wang, J Li, Y T Guo, J Li, J Li, J Y Lin. Sebaceous gland carcinoma of the eyelid co-occurred with other tumors: a report of four cases]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology. 2024 Nov 11;60(11):921-926

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PMID: 39505378

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