Does glucomannan supplementation exert profitable effects on serum lipid profile in adults? A systematic review and meta-analysis.

Considering dyslipidemia's impact on cardiovascular disease and even chronic illnesses and the beneficial effect of glucomannan on dyslipidemia, this study aimed to examine how glucomannan affects lipid profile parameters thoroughly. Using standard keywords, the databases Scopus, PubMed, Embase, Web of Science databases, and Google Scholar were searched from inception to December 2024. Based on our finding, glucomannan significantly reduced total cholesterol (TC) (SMD: -2.26; 95 % CI: -2.98, -1.55, p <0.001), low-density lipoprotein cholesterol (LDL-C) levels (SMD: -2.57; 95 % CI: -3.41, -1.74; p<0.001), but not effect on high-density lipoprotein cholesterol (HDL-C) (SMD: -0.33; 95 % CI: -0.70, 0.03, p=0.075), and triglyceride (TG) (SMD: -0.16; 95 % CI: -0.59, 0.27, p =0.473). However, these significant decreases are not clinically important. Therefore, glucomannan only can be considered as an adjunctive therapeutic approach in managing dyslipidemia. Copyright © 2024 Elsevier Inc. All rights reserved.

Citation

Zhu Haijun, Zhang Ke, Zhang Dawei, Amir Reza Haedi, Elika Poorasadollah, Cheng Cheng. Does glucomannan supplementation exert profitable effects on serum lipid profile in adults? A systematic review and meta-analysis. Prostaglandins & other lipid mediators. 2025 Jan;176:106934

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PMID: 39528010

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