Hierarchical Analysis of Protein Structures: From Secondary Structures to Protein Units and Domains.

The three-dimensional structure of proteins is traditionally organized into hierarchical levels, specifically secondary structures and domains. However, different studies suggest the existence of intermediate levels, such as Protein Units (PUs), which provide a refined understanding of protein architecture. PUs, characterized by their compactness and independence, serve as an intermediate organizational level, bridging the gap between secondary structures and domains. This new view not only enhances our comprehension of protein structure, folding, and evolutionary mechanisms but also provides a robust methodology for identifying and categorizing protein domains. Based on the concept of PUs, alternative structural partitioning solutions can be proposed that address the structural ambiguity of proteins, leading to more meaningful domain identification. © 2025. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

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Charlotte Perin, Gabriel Cretin, Jean-Christophe Gelly. Hierarchical Analysis of Protein Structures: From Secondary Structures to Protein Units and Domains. Methods in molecular biology (Clifton, N.J.). 2025;2870:357-370

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PMID: 39543044

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