Clear Search sequence regions


  • apoptosis (1)
  • benzhydryl compounds (2)
  • bisphenol (10)
  • blastocyst (1)
  • cumulus cells (5)
  • embryos (1)
  • female (1)
  • impairs (1)
  • oocyte (9)
  • oxygen (3)
  • phenols (2)
  • reticulum (1)
  • species (3)
  • steroid (1)
  • swine (1)
  • toxic effects (1)
  • Sizes of these terms reflect their relevance to your search.

    Bisphenol A (BPA) is a well-known environmental endocrine disruptor that has detrimental effects on reproduction. This study aimed to investigate whether BPA exposure could disrupt the function of cumulus cells and influence oocyte maturation and development. Porcine oocytes at the germinal vesicle stage were exposed to BPA for 44 h. The results revealed that BPA exposure led to dysfunction in cumulus cells by inhibiting meiotic division, inducing endoplasmic reticulum stress, and disrupting steroid synthesis. Furthermore, BPA exposure significantly increased reactive oxygen species and caused abnormal distribution of mitochondria in the oocytes. Notably, matured oocytes in the MII stage from the BPA-exposed groups showed significantly reduced development to the blastocyst stage, along with increased autophagy and apoptosis. These findings suggest that cumulus-oocyte complexes are sensitive to BPA exposure during the germinal vesicle stage, and the toxic effects of BPA on cumulus cells can severely inhibit oocyte and parthenogenetic embryos development. Copyright © 2024 Elsevier Inc. All rights reserved.

    Citation

    Yajie Chen, Shuang Zhang, Yifan Sun, Jialun Zou, Xuan Qiu, Haotong Xi, Yongnan Xu, Yinghua Li, Bangzhu Chen, Jianglin Fan, Maobi Zhu. Bisphenol A impairs oocyte maturation by dysfunction of cumulus cells. Theriogenology. 2025 Feb;233:139-146

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 39615448

    View Full Text