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Central tolerance restricts T cells that target self-antigens. In this issue of Immunity, Abdelfattah et al.1 describe a method to generate self-reactive T cell receptors (TCRs) by directed evolution of non-autoreactive TCRs to recognize self-antigen peptides and demonstrate potential for T cells engineered with such receptors in immunotherapy. Copyright © 2024 Elsevier Inc. All rights reserved.
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Andrew Y Hu, Cristina Puig-Saus. T-switch-ing TCR specificity. Immunity. 2024 Dec 10;57(12):2717-2719
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PMID: 39662088
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