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Beyond pluripotency: Yamanaka factors drive brain growth and regeneration.

Sunwoo Choi, Mingzi Zhang, Ruslan Rust

Trends in molecular medicine 2025 Feb


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    The Yamanaka factors (YFs), a set of four transcription factors, are widely studied for their ability to dedifferentiate somatic cells into a pluripotent state. In a recent study, Shen and colleagues show that transient expression of YFs in the mouse brain expands the developing cortex and prevents cognitive decline in an Alzheimer's disease (AD) model. Copyright © 2024 Elsevier Ltd. All rights reserved.

    Citation

    Sunwoo Choi, Mingzi Zhang, Ruslan Rust. Beyond pluripotency: Yamanaka factors drive brain growth and regeneration. Trends in molecular medicine. 2025 Feb;31(2):100-102

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    PMID: 39668101

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    • Copyright © 2025 Illumina Inc. All rights reserved.