Adrenomedullin in pulmonary hypertension.

Adrenomedullin (AM) exerts strong pulmonary vasodilatory effects. These effects are mediated in part by nitric oxide. Plasma AM levels are increased in patients with pulmonary hypertension and correlate with disease severity and poor outcomes. Acute administration of AM improves the haemodynamics in patients with pulmonary hypertension, while chronic administration prevents the onset of pulmonary hypertension in animal models and delays its progression. Thus, AM is closely related to the pathophysiology of pulmonary hypertension and may be a promising therapeutic target. Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.

Citation

Toshio Nishikimi, Hideyuki Kinoshita, Hideaki Inazumi, Takahiko Kanamori, Hiromu Yanagisawa, Kenji Moriuchi, Yasuaki Nakagawa. Adrenomedullin in pulmonary hypertension. Danish medical journal. 2024 Nov 15;71(12)

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PMID: 39749558

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