Anion Transport by Bambusuril-Bile Acid Conjugates: Drastic Effect of the Cholesterol Content.

Artificial anion transporters offer a potential way to treat deficiencies in cellular anion transport of genetic origins. In contrast to the large variety of mobile anion carriers and self-assembled anion channels reported, unimolecular anion channels are less investigated. Herein, we present a unique example of a unimolecular anion channel based on a bambusuril (BU) macrocycle, a well-established anion receptor. The BU structure was expanded by appending various bile acid residues allowing a single molecule to span the membrane. Chloride transport mediated by BUs through lipid bilayers was investigated in liposomes and these studies revealed a surprisingly high dependence of the anion transport activity on the cholesterol content in the liposomal membrane. © 2025 The Author(s). Angewandte Chemie International Edition published by Wiley-VCH GmbH.

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Jacopo Torrisi, Matúš Chvojka, Pia Jurček, Xinxin Zhang, Huaqiang Zeng, Vladimír Šindelář, Hennie Valkenier. Anion Transport by Bambusuril-Bile Acid Conjugates: Drastic Effect of the Cholesterol Content. Angewandte Chemie (International ed. in English). 2025 Feb 24;64(9):e202424754

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PMID: 39791967

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