Curvature Memory in Electrically Stimulated Lipid Membranes.

We demonstrate, using non-equilibrium molecular dynamics simulations, that lipid membrane capacitance varies with surface charge accumulation linked to membrane shape and curvature changes. Specifically, we show that lipid membranes exhibit a hysteretic response when exposed to oscillatory electric fields. The electromechanical coupling in these membranes leads to hysteretic buckling, in which the membrane can spontaneously buckle in one of two distinct directions along the electric field, even for the same ionic charge accumulation at the water-membrane interface. In this regard, these binary buckled membrane states suggest potential applications in neuromorphic computing. Their bistable nature, characterized by two distinct and stable configurations, could serve as a foundation for implementing memory storage systems and logic operations. Furthermore, we introduce a circuit model that captures these dynamic effects, offering insights into emergent memory effects in electrically stimulated lipid membranes. Finally, this work presents lipid bilayers as dynamic, adaptable elements and suggests a new platform for exploring energy storage, information processing, and memory encoding at the lipid membrane level.

Citation

Maxim O Lavrentovich, Jan-Michael Y Carrillo, Charles Patrick Collier, John Katsaras, Dima Bolmatov. Curvature Memory in Electrically Stimulated Lipid Membranes. Langmuir : the ACS journal of surfaces and colloids. 2025 Feb 11;41(5):3157-3165

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PMID: 39871541

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