Small intestine changes, large intestine problems.

Deepanshu Singla, Abigail E Rose, Wenhan Zhu

Trends in microbiology 2025 Mar

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Enteric pathogens must overcome host microbiota-mediated colonization resistance to colonize the gut. Radlinski et al. discovered that Salmonella invasion of the small intestine leads to amino acid malabsorption. This increases amino acid availability in the large intestine, fueling Salmonella colonization through amino acid decarboxylation and counteracting SCFA-mediated cytoplasmic acidification. Copyright © 2025 Elsevier Ltd. All rights reserved.