Unlocking the Potential of Extracellular Vesicles in Cardiovascular Disease.

Extracellular vesicles (EVs) are micro-nanoscale biological particles encapsulated by phospholipid bilayers, which regulate cell migration, angiogenesis and tumour cell growth by transmitting various biomolecules such as nucleic acids and proteins. EVs are composed of exosomes, microparticles and apoptotic bodies. Its benefits pass through biofilms and are not degraded by various enzymes, so it can be used as a biomarker in potential diseases and has attracted much attention from researchers. Current studies have found that EVs are involved in the development of various cardiovascular diseases (CVD), such as heart failure and myocardial ischemia-reperfusion injury. In addition, stem cell-derived EVs play an important role in the diagnosis and treatment of a variety of CVD. In this review, we present the biological features of EVs, the role of EVs in various CVD, and the challenges they encounter in the treatment of CVD. © 2025 The Author(s). Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

Citation

Hanbin Li, Lu Wang, Hongxin Cheng, Qing Zhang, Shiqi Wang, Wen Zhong, Chengqi He, Quan Wei. Unlocking the Potential of Extracellular Vesicles in Cardiovascular Disease. Journal of cellular and molecular medicine. 2025 Feb;29(3):e70407

Mesh Tags

Substances

PMID: 39910696

search → result