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Indirect CD4+ T cell allorecognition of donor peptides presented by host MHC class II antigens contributes to transplant rejection in part by eliciting donor-specific antibodies (DSAs). In this issue of Immunity, Zhanzak et al. revisit the role of indirectly alloreactive CD4+ T cells in transplantation and demonstrate that immunodominant epitopes stimulate a narrow repertoire of T cells that can be pruned to prevent DSA formation. Copyright © 2025 Elsevier Inc. All rights reserved.
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Anita S Chong, Marlena Habal. Cutting to the chase: Pruning alloreactive T cells. Immunity. 2025 Feb 11;58(2):270-272
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PMID: 39938479
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