5-Substituted-2,2'-anhydrouridines, potent inhibitors of uridine phosphorylase.

5-Substituted-2,2'-anhydrouridines are a new class of competitive inhibitors of uridine phosphorylase. The most potent member of the series is 2,2'-anhydro-5-ethyluridine with an apparent Ki value of 25 nM. These compounds are selective inhibitors of uridine phosphorylase and have no effect on thymidine phosphorylase. 5-Substituted-2,2'-anhydrouridines are no substrates of either uridine phosphorylase or thymidine phosphorylase.

Citation

Z Veres, A Szabolcs, I Szinai, G Dénes, M Kajtár-Peredy, L Otvös. 5-Substituted-2,2'-anhydrouridines, potent inhibitors of uridine phosphorylase. Biochemical pharmacology. 1985 May 15;34(10):1737-40

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PMID: 4004890

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