A Narrative Review on Plant Extracts for Metabolic Syndrome: Efficacy, Safety, and Technological Advances.

Metabolic syndrome, a global health concern, is characterized by visceral obesity, hyperglycemia, dyslipidemia, hypertension, and chronic low-grade inflammation. Current therapeutic options are limited by their varying efficacy and significantly adverse side effects, fueling interest in natural products, particularly plant extracts, as potential preventive interventions for high-risk individuals. This review examines the role of plant extracts in mitigating metabolic syndrome risk factors, addressing safety concerns and exploring associated technological advancements. The literature indicates that plant extracts hold promise for addressing the pathophysiology of metabolic dysfunction. However, challenges such as safety concerns, a lack of standardized regulation, and potential drug-plant interactions currently limit their clinical application. Rigorous, long-term clinical trials are necessary to confirm the efficacy and safety of plant extracts before they can be established as a preventive strategy for managing metabolic syndrome.

Citation

Hammad Ullah, Marco Dacrema, Daniele Giuseppe Buccato, Marwa A A Fayed, Lorenza Francesca De Lellis, Maria Vittoria Morone, Alessandro Di Minno, Alessandra Baldi, Maria Daglia. A Narrative Review on Plant Extracts for Metabolic Syndrome: Efficacy, Safety, and Technological Advances. Nutrients. 2025 Feb 28;17(5)

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PMID: 40077747

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