The comparative potency of phenobarbital and five 1,3-propanediol dicarbamates for hepatic cytochrome P450 induction in rats.

F H Segelman, E Kelton, R M Terzi, N Kucharczyk, R D Sofia

Research communications in chemical pathology and pharmacology 1985 Jun

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Using a reproducible screening procedure for rat liver cytochrome P450 isoenzyme induction/inhibition, five dicarbamate drugs (meprobamate, mebutamate, carisoprodol, tybamate, and W-554) were compared with sodium phenobarbital and found to be from 25 to 100 times less potent hepatic cytochrome P450 inducers than phenobarbital.

Citation

F H Segelman, E Kelton, R M Terzi, N Kucharczyk, R D Sofia. The comparative potency of phenobarbital and five 1,3-propanediol dicarbamates for hepatic cytochrome P450 induction in rats. Research communications in chemical pathology and pharmacology. 1985 Jun;48(3):467-70