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The structures of WB-3559 A, B, C and D, new fibrinolytic agents isolated from Flavobacterium sp. No. 3559, have been elucidated to be as shown in 1, 2, 3 and 4, respectively, on the basis of chemical and spectroscopic evidence. Total synthesis of WB-3559 D (4) was achieved starting from the optically active aldehyde 14.


I Uchida, K Yoshida, Y Kawai, S Takase, Y Itoh, H Tanaka, M Kohsaka, H Imanaka. Studies on WB-3559 A, B, C and D, new potent fibrinolytic agents. II. Structure elucidation and synthesis. The Journal of antibiotics. 1985 Nov;38(11):1476-86

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PMID: 4077727

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