Homozygous Hb J Tongariki: evidence for only one alpha chain structural locus in Melanesians.

A high frequency of Hb J Tongariki (alpha 115 Ala --> Asp) was found in a Kilenge village in New Britain. Heterozygotes had 45 to 50 percent of the Hb J component (determined by cellulose acetate electrophoresis). Two homozygotes for Hb J had no Hb A, suggesting that in this family only one Hbalpha structural locus is present.

Citation

R K Abramson, D L Rucknagel, D C Shreffler, J J Saave. Homozygous Hb J Tongariki: evidence for only one alpha chain structural locus in Melanesians. Science (New York, N.Y.). 1970 Jul 10;169(941):194-6

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PMID: 5427353

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