Immunopharmacologic properties of WY-16,922, a new orally effective antiallergic agent.

In a series of tests designed to illustrate immune reactions similar to those obtained in atopic disease, Wy-16,922 effectively inhibited reaginic-mediated immunologic reactions in the skin, longs and mast cell. It was found to be devoid of immunosuppressant, antimediator, anti-inflammatory, steroid or bronchodilator properties as well as acute toxicity. Although the mechanism of action Wy-16,922 is unknown, it appears to limit the release (not the effects) of allergic mediators in a manner similar to that described for disodium cromoglycate.

Citation

M E Rosenthale, A J Begany, A Dervinis, J Sellstedt, C Guinosso, M I Gluckman. Immunopharmacologic properties of WY-16,922, a new orally effective antiallergic agent. The Journal of pharmacology and experimental therapeutics. 1976 Apr;197(1):153-62

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PMID: 57234

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