Salivary epithelium in culture, under conditions which promote morphogenetic branching, grows as a simple disc in the presence of collagenase, or is "depatterned" midway in the morphogenetic course by a short exposure to a collagenase.
C Grobstein, J Cohen. Collagenase: effect on the morphogenesis of embryonic salivary epithelium in vitro. Science (New York, N.Y.). 1965 Oct 29;150(3696):626-8
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PMID: 5837103
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