A new variant of the normal minor component Hb A(2) has been detected in a family that lives in Sphakiá, Crete. Chemical studies of this abnormal hemoglobin, designated Hb A(2) delta Sphakiá, indicates a substitution of the histidyl residue number two of the delta-chain by an arginyl residue.
R T Jones, B Brimhall, E R Huehns, N A Barnicot. Hemoglobin Sphakiá: a delta-chain variant of hemoglobin A2 from Crete. Science (New York, N.Y.). 1966 Mar 18;151(716):1406-8
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PMID: 5909792
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