The dynamics of drug release from suppositories. Part 6: The effects of lipophil and hydrophilic suppository bases on the release of adeiphenin (author's transl)].

On studying the release of adiphenin from suppositories, the authors found that it is most rapid from hydrophilic bases. The release rate decreased in the following order: PEG 1500 leads to PEG 2000 leads to PEG 4000 (70%) + Glycerol (30%) leads to PEG 1000 (70%) + Peg 4000 (30%) leads to PEG 4000 leads to PEG 6000. The release is considerably slower from the bases Witepsol W35, Witepsol H15 and cacao butter.

Citation

J Pasich, B Brobnicka, A Kasprzyk. The dynamics of drug release from suppositories. Part 6: The effects of lipophil and hydrophilic suppository bases on the release of adeiphenin (author's transl)]. Die Pharmazie. 1980;35(7):416-7

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PMID: 6106209

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