Conversion of 14C-labeled eicosapentaenoic acid (n-3) to leukotriene C5.

14C-labeled eicosapentaenoic acid (n-3) was converted by mouse mastocytoma cells to 5-hydroxy-6-S-glutathionyl-7,9,11,14,17-eicosapentaenoic acid (leukotriene C5). The identification was based on comparisons with previously characterized unlabeled material by high-performance liquid chromatography, ultraviolet spectroscopy, and conversion by gamma-glutamyl transpeptidase to leukotriene D5.

Citation

S Hammarström. Conversion of 14C-labeled eicosapentaenoic acid (n-3) to leukotriene C5. Biochimica et biophysica acta. 1981 Feb 23;663(2):575-7

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PMID: 6111355

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