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The effect of new antihistaminic drugs, phencarol and bicarphen, on immunologic reactivity of experimental animals was studied in comparison with diphenhydramine. Phencarol and bicarphen inhibited the delayed type allergic reactions to a greater degree than diphenydramine. Unlike diphenhydramine, phencarol and bicarphen injected simultaneously with test-antigen markedly decreased the number of rosette-forming lymphocytes in the immunocompetent organs (spleen, thymus, lymph nodes). Phencarol, bicarphen and diphenhydramine produced the same inhibitory effect on the content of antibody-producing cells in the spleen of mice.


M D Mashkovskiĭ, I G Veksler, M E Kaminka, V A Iakimenko. Effect of new antihistaminic preparations on the body's immunologic reactivity]. Biulleten' eksperimental'noĭ biologii i meditsiny. 1981 Mar;91(3):340-2

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PMID: 6113860

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