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A randomized study of the induction agents Midazolam and Hypnomidate on 20 patients without cardiovascular disease only showed a minimal effect of both agents on blood pressure, heart rate and myocardial function. Inspite of small differences after injection of Midazolam or Hypnomidate, neither of the agents appears superior to the other. Midazolam is an i.v. induction agent with minimal cardiovascular effect and good hypnotic properties.

Citation

W F List, H Ponhold. Comparative study of the effect of midazolam and hypnomidate on the cardiovascular system]. Der Anaesthesist. 1983 Aug;32(8):395-8

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PMID: 6137970

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