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In this paper the authors have carried out further research on the differentiation of six-day limb skin from chick embryos cultured in vitro in mediam containing histones. When 3H-uridine is added to this modified medium, a decrease of 3H-uridine uptake and incorporation is observed. The authors conclude that in their system the histones not only interfere with the regulation of genetic transcription by inhibiting DNA-dependent RNA synthesis, but they also change cellular permeability.


P Locci, M Boda, F Fronticelli, F Mosci, A Bodo. Incorporation of H3 uridine in chick embryo skin cultured in media containing histones]. Bollettino della Società italiana di biologia sperimentale. 1981 Apr 30;57(8):853-6

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PMID: 6168274

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