Three cases of generalized skin reactions occurred in patients undergoing oral therapy with Fenbufen (Cinopal), a new anti-inflammatory agent. The lesions spontaneously improved when the drug was discontinued. The role of Fenbufen in the pathogenesis of the lesions remains unclear. In the three cases, the detection of circulating immune complexes would suggest a sensibilization mechanism.
C Nicolas, B Chouvet, F Cambazard, C Bernollin, J Thivolet. Skin lesions related to a new anti-inflammatory agent: fenbufen. Apropos of 3 clinical cases]. Annales de dermatologie et de vénéréologie. 1983;110(5):419-23
PMID: 6226230
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