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Administration of cGMP immediately after an operation caused the early activations of collagen biosynthesis in skin, muscles and granulations. Within the 5 day content on collagen was increased two-fold in granulations of experimental animals as compared with controls. Stimulation of the label incorporation into some muscle proteins and intensification of glycogen metabolism were also observed after the cGMP treatment. Morphologic analysis of tissues and measurement of the wound area in dynamics of healing were carried out. The data obtained suggest that administration of cGMP into the operated animals activated metabolism in wound tissues and stimulated their healing.


M A Zaidenberg, R N Korotkina, I M Nosova, G N Dudnikova, S A Pisarzhevskii. Effect of cGMP administration on certain metabolic processes in rat wound tissues]. Voprosy medit͡sinskoĭ khimii. 1980 Nov-Dec;26(6):770-4

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PMID: 6256965

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