Evaluation of the 4-pyridinemethanol WR 180,409 (enpiroline) in the treatment of induced Plasmodium falciparum infections in healthy, non-immune subjects.

T M Cosgriff, E F Boudreau, C L Pamplin, J D Berman, M J Shmuklarsky, C J Canfield

The American journal of tropical medicine and hygiene 1984 Sep

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WR 180,409 (enpiroline) was administered to 22 non-immune subjects infected with the multi-drug resistant Vietnam Smith isolate of Plasmodium falciparum. It was curative in single day treatment regimens with a minimum curative dose of approximately 10 mg/kg body weight. At this dose level it was well tolerated and produced rapid clearance of parasitemia in every case.

Citation

T M Cosgriff, E F Boudreau, C L Pamplin, J D Berman, M J Shmuklarsky, C J Canfield. Evaluation of the 4-pyridinemethanol WR 180,409 (enpiroline) in the treatment of induced Plasmodium falciparum infections in healthy, non-immune subjects. The American journal of tropical medicine and hygiene. 1984 Sep;33(5):767-71