Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets.

J R Falck, S Manna, J Moltz, N Chacos, J Capdevila

Biochemical and biophysical research communications 1983 Jul 29

filter terms:

Metapyrone and eicosatetraynoic acid but not indomethacin are effective inhibitors of the secretory response of isolated rat pancreatic islets to arginine and glucose. Epoxyeicosatrienoic acids, products of the cytochrome P-450-NADPH dependent arachidonic acid epoxygenase activity, are potent and selective mediators for the in vitro release of either insulin or glucagon from preparations of isolated rat pancreatic islets.

Citation

J R Falck, S Manna, J Moltz, N Chacos, J Capdevila. Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets. Biochemical and biophysical research communications. 1983 Jul 29;114(2):743-9