Antineoplastic agents, 103. The isolation and structure of hypoestestatins 1 and 2 from the East African Hypoëstes verticillaris.

G R Pettit, A Goswami, G M Cragg, J M Schmidt, J C Zou

Journal of natural products 1984 Nov-Dec

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The East African shrub Hypoëstes verticillaris representing a heretofore chemically unexplored. Acanthaceae genus has been found to contain two new cell growth inhibitory (murine P-388 lymphocytic leukemia) phenanthroindolizidine alkaloids termed hypoestestatin 1 (1a) and hypoestestatin 2 (1b). Both substances were found to markedly inhibit growth of the murine P-388 cell line (ED50 = 10(-5) micrograms/ml). The structures of hypoestestatins 1 and 2 were assigned primarily on the basis of results from extensive spectral studies.

Citation

G R Pettit, A Goswami, G M Cragg, J M Schmidt, J C Zou. Antineoplastic agents, 103. The isolation and structure of hypoestestatins 1 and 2 from the East African Hypoëstes verticillaris. Journal of natural products. 1984 Nov-Dec;47(6):913-9