Evaluation of the antimalarial activity of the phenanthrenemethanol halofantrine (WR 171,669).

T M Cosgriff, E F Boudreau, C L Pamplin, E B Doberstyn, R E Desjardins, C J Canfield

The American journal of tropical medicine and hygiene 1982 Nov

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Halofantrine (WR 171,669) was administered to 27 nonimmune subjects infected with the multi-drug resistant Vietnam Smith strain of Plasmodium falciparum. It was also administered to three other subjects, one infected with the Cambodian Buchanan strain of P. falciparum, and two with blood-induced infection with the Chesson strain of P. vivax. It cured infections with all three parasites. Against the highly chloroquine-resistant Smith strain, it was curative in single day treatment regimens. The drug was well tolerated and produced rapid clearance of parasitemia in every case.

Citation

T M Cosgriff, E F Boudreau, C L Pamplin, E B Doberstyn, R E Desjardins, C J Canfield. Evaluation of the antimalarial activity of the phenanthrenemethanol halofantrine (WR 171,669). The American journal of tropical medicine and hygiene. 1982 Nov;31(6):1075-9