Antineoplastic and curative antileukemic activity of 1,4-benzoquinone guanylhydrazone thiosemicarbazone and its hydrochloride on in vivo murine models].

W Gutsche, W Schulze, W Jungstand, K Wohlrabe

Die Pharmazie 1983 Feb

filter terms:

By means of four murine models, the authors demonstrated in vivo that 1,4-benzoquinone guanylhydrazone thiosemicarbazone (1), which is known to be antimicrobially active, and its hydrochloride (2) exert an antineoplastic effect. In leukaemia P 388 and leukaemia L 1210 both compounds had a curative action already after four oral administrations. The "cured" animals were resistant or cross-resistant to further transmissions of leukaemia. The resistance was transmissible by splenocytes.

Citation

W Gutsche, W Schulze, W Jungstand, K Wohlrabe. Antineoplastic and curative antileukemic activity of 1,4-benzoquinone guanylhydrazone thiosemicarbazone and its hydrochloride on in vivo murine models]. Die Pharmazie. 1983 Feb;38(2):105-7