Studies on WF-3161, a new antitumor antibiotic.

WF-3161 is an antitumor antibiotic produced by a strain of fungus, Petriella guttulata. The antibiotic was purified by solvent extraction and a combination of silica gel and reverse phase column chromatography. The chemical structure of the antibiotic (C31H44N4O6, mp 181-183 degrees C) was found to be a cyclic tetrapeptide consisting of phenylalanine, leucine, pipecolinic acid and 2-amino-8-oxo-9,10-epoxydecanoic acid. WF-3161 inhibited the growth of Trichophyton asteroides. It prolonged survival period of mice bearing leukemia P-388 with a high therapeutic index.

Citation

K Umehara, K Nakahara, S Kiyoto, M Iwami, M Okamoto, H Tanaka, M Kohsaka, H Aoki, H Imanaka. Studies on WF-3161, a new antitumor antibiotic. The Journal of antibiotics. 1983 May;36(5):478-83

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PMID: 6860430

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