The role of metabolic factors in the interaction between opiates and homopyrimidazoles in the central nervous system.

Both the analgesic and the antitussive effects of morphine, codeine and azidomorphine, azidocodeine and azidoethylmorphine are potentiated in rats and cats by Probon, a minor analgesic, with a homopyrimidazole structure. The analgesic effect of opiates and their toxicity are more strongly influenced by the N-methylhomopyrimidazoles than their antitussive effect. In the potentiation between Probon and morphine derivatives metabolic interference may play a role at the N-demethylation level, occuring in the liver microsomes.

Citation

K Magyar, L G Härsing, K Tekes, J Knoll. The role of metabolic factors in the interaction between opiates and homopyrimidazoles in the central nervous system. Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement. 1980;4:376-9

Mesh Tags

Substances

PMID: 6933941

search → result