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Both the analgesic and the antitussive effects of morphine, codeine and azidomorphine, azidocodeine and azidoethylmorphine are potentiated in rats and cats by Probon, a minor analgesic, with a homopyrimidazole structure. The analgesic effect of opiates and their toxicity are more strongly influenced by the N-methylhomopyrimidazoles than their antitussive effect. In the potentiation between Probon and morphine derivatives metabolic interference may play a role at the N-demethylation level, occuring in the liver microsomes.

Citation

K Magyar, L G Härsing, K Tekes, J Knoll. The role of metabolic factors in the interaction between opiates and homopyrimidazoles in the central nervous system. Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement. 1980;4:376-9

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PMID: 6933941

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