Formation of mutagens by sorbic acid-nitrite reaction: effects of reaction conditions on biological activities.

M Namiki, S Udaka, T Osawa, K Tsuji, T Kada

Mutation research 1980 Nov

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Conditions of the reaction between sorbic acid and sodium nitrite generating mutagenic principles were examined. In the rec-assay and the Ames reversion assay, the maximal mutagenic activity was obtained in a pH range of 3.5-4.2. Mutagenic and growth-inhibitor activities of five C-nitro and C-nitroso compounds were studied. The product Y, 2-methyl-1,4-dinitropyrrole, was the strongest mutagen among them.

Citation

M Namiki, S Udaka, T Osawa, K Tsuji, T Kada. Formation of mutagens by sorbic acid-nitrite reaction: effects of reaction conditions on biological activities. Mutation research. 1980 Nov;73(1):21-8