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The effects of insulin on the in vitro fibrinolytic activity and on the ability to ingest inert latex particles of murine peritoneal macrophages were studied. The addition to the cell cultures of insulin at the concentration of 25 ng/ml significantly increased both fibrinolytic and phagocytic activities. These findings suggest that insulin may play an important role not only in the regulation of the cellular metabolic process but that also directly modulates specific cell functions.


F Ghezzo, G Garbarino, B Giovinazzo, L Ioverno. Effects of insulin on fibrinolytic and phagocytic activity of peritoneal macrophages in mice]. Bollettino della Società italiana di biologia sperimentale. 1982 Mar 15;58(5):200-3

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PMID: 7041924

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