Effect of central m- and n-cholinergic agents on ovarian compensatory hypertrophy in rats].

Stimulation of the n-cholinergic structures by nicotine or depression of m-cholinergic structures by metamizyl inhibited the compensatory ovarian hypertrophy (COH) induced by hemiovariectomy in rats. Stimulation of m-cholinergic structure by arecoline or depression of n-cholinergic structures by n-cholinolytic IEM-506 eliminated the suppression of COH induced by diethylstilbestrol-propionate. The mediatory role of the central-m-cholinergic systems in the mechanisms of COH and that of n-cholinergic systems in the estrogen-induced suppression of COH is suggested.

Citation

V N Anisimov. Effect of central m- and n-cholinergic agents on ovarian compensatory hypertrophy in rats]. Problemy ėndokrinologii. 1978 Sep-Oct;24(5):85-7

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PMID: 704564

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