Antianginal effect of nifedipine after intracoronary and intravenous administration judged by reduction of ischemic ST-segment depression in exercise tests.

The purpose of the study was to distinguish between the peripheral and the cardiac mode of action of nifedipine, a drug which inhibits transmembrane calcium transport. To assess the cardiac and peripheral antianginal effect independently, two routes of application were employed: systemic intravenous and intracoronary infusion into the left coronary artery of approximately equipotent doses.

Citation

W Schulz, M Kaltenbach. Antianginal effect of nifedipine after intracoronary and intravenous administration judged by reduction of ischemic ST-segment depression in exercise tests. Cardiology. 1981;68 Suppl 2:200-8

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PMID: 7317898

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