Inhibition by idrocilamide of the disposition of caffeine.

J L Brazier, J Descotes, N Lery, M Ollagnier, J C Evreux

European journal of clinical pharmacology 1980 Jan

filter terms:

The pharmacokinetics of caffeine are greatly altered by concomitant administration of idrocilamide. In four healthy volunteers id rocilamide inhibited the biotransformation of caffeine and increased its half-life nine times. The untoward neuropsychiatric effects of idrocilamide are the consequence of abnormal accumulation of caffeine in regular consumers of caffeine-containing foods and beverages.

Citation

J L Brazier, J Descotes, N Lery, M Ollagnier, J C Evreux. Inhibition by idrocilamide of the disposition of caffeine. European journal of clinical pharmacology. 1980 Jan;17(1):37-43