New anticoccidial antibiotics, WS-5995 A and B. I. Isolation and characterization.

WS-5995 A, B and C are produced by a new strain of Streptomyces designated Streptomyces auranticolor. These antibiotics were purified by solvent extraction followed by chromatography on silica gel and then crystallized. WS-5995 A (C19H12O6, m.p., 289 approximately 291 degrees C) and WS-5995 B (C19H14O6, sublimation at 300 degrees C) protect chickens from infection with Eimeria tenella, a species of coccidia, which produces morbidity or mortality in chickens. WS-5995 C (C19H14O 7, m.p. 288 approximately 290 degrees C), a biologically inactive component, was found to be converted to WS-5995 A on treatment with trifluoroacetic anhydride.

Citation

H Ikushima, M Okamoto, H Tanaka, O Ohe, M Kohsaka, H Aoki, H Imanaka. New anticoccidial antibiotics, WS-5995 A and B. I. Isolation and characterization. The Journal of antibiotics. 1980 Oct;33(10):1107-13

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PMID: 7451360

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