Hypocrellin B-ethanolamine (HB-E) sensitized photodamage on rat mitochondria].

The Hypocrellin B-Ethanolamine (HB-E) sensitized photodamage on lipid peroxidation, sulfhydryl oxidation and ATPase inactivation of rat liver mitochondria was studied under illumination of 640 nm, The HB-E sensitized photodamage of lipid peroxidation is less than sulfhydryl photooxidation, when HB-E concentration is 50 mumol/L. To elucidate the mechanism of photodamage of HB-E, antioxidant: BHT, Vit E, oxygen radical quencher: L-His, beta-Cart, were investigated. The results showed that HB photodamage of mitochondria is not only by oxygen radical, but also by HB-E radical as well. From compared tests among HB, HA, Hp, MB and HB-E, we found that HB-E had higher ability to photodamage lipid peroxidation, sulfhydryl oxidation and tryptophan than other photosensitizers. The experiments showed that the superoxide generated may be by HB-E radical.

Citation

J C Yue, M Liu, P Wan, S Z Pang. Hypocrellin B-ethanolamine (HB-E) sensitized photodamage on rat mitochondria]. Shi yan sheng wu xue bao. 1995 Mar;28(1):23-30

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PMID: 7597866

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