Antisense oligonucleotides containing 1-(beta-D-2'-deoxy-threo-pentofuranosyl)thymine at the 3'- and 5'-end].

N F Krynetskaia, O A Chebotar', K Kh Ibragim, E A Romanova, V N Tashlitskiĭ, T S Oretskaia, N I Sokolova, Z A Shabarova

Bioorganicheskaia khimiia 1994 Jun

filter terms:

Oligonucleotides with 3'- and 5'-terminal 1-(beta-D-2'-deoxy-threo-pentafuranosyl)thymin residues (inversion at C3'-atom) were obtained by the automatic phosphoramidite synthesis. The modifications protect oligonucleotides from the nuclease degradation and do not affect the stability of nucleic acid duplexes.

Citation

N F Krynetskaia, O A Chebotar', K Kh Ibragim, E A Romanova, V N Tashlitskiĭ, T S Oretskaia, N I Sokolova, Z A Shabarova. Antisense oligonucleotides containing 1-(beta-D-2'-deoxy-threo-pentofuranosyl)thymine at the 3'- and 5'-end]. Bioorganicheskaia khimiia. 1994 Jun;20(6):669-75