Interleukin-1 receptor type I mRNA in mouse brain as affected by peripheral administration of bacterial lipopolysaccharide.

N Reinisch, M Wolkersdorfer, C M Kähler, K Ye, C A Dinarello, C J Wiedermann

Department of Internal Medicine, University of Innsbruck, Austria.

Neuroscience letters 1994 Jan 31

filter terms:

Following administration of endotoxin in vivo, alterations of interleukin-1 (IL-1) receptor binding have been reported. In order to assess in vivo regulation of IL-1 receptor gene expression in brain, mRNA levels for IL-1 receptor type I were measured after peripheral administration of bacterial lipopolysaccharide in mice. When 25 micrograms of lipopolysaccharide were administered intraperitoneally, IL-1 receptor type I mRNA in the brain was increased after 3 h. After 20 h, the level was diminished. This result suggests that bacterial lipopolysaccharide affects regulation of IL-1 receptor type I mRNA expression in mouse brain.

Citation

N Reinisch, M Wolkersdorfer, C M Kähler, K Ye, C A Dinarello, C J Wiedermann. Interleukin-1 receptor type I mRNA in mouse brain as affected by peripheral administration of bacterial lipopolysaccharide. Neuroscience letters. 1994 Jan 31;166(2):165-7