A model of positive rRNA gene expression regulation based on complementary interaction of transcripts of the prealbumin gene introns with its promotors].

A B Fonarev, I B Krashakova, M A Fonarev, I N Todorov

Molekuliarnaia biologiia 1993 Nov-Dec

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The present paper is concerned with computation of the homology between the promoter and spacer sequences of the rRNA gene and the prealbumin introns. Both the sense and antisense strands of the promoters were compared with the introns. The rRNA promoters were found to contain a considerable number of prealbumin-homologous intron sites on the coding strand only, whereas the spacer sequence had the intron-homologous sites on both strands. The fragments homologous to the ribosome gene promoter regions are mainly concentrated in the first prealbumin intron. The oncogene, glycoprotein and the interleukin intron fragments revealed no sites homologous to the ribosome gene promoter. A model has been proposed for positive regulation of the rRNA gene expression via complementary interaction between the transcripts of the prealbumin gene introns with sense and antisense strands of the rRNA promoters. It is believed that either positive or negative regulation of the ribosome biogenesis can be achieved in this way.

Citation

A B Fonarev, I B Krashakova, M A Fonarev, I N Todorov. A model of positive rRNA gene expression regulation based on complementary interaction of transcripts of the prealbumin gene introns with its promotors]. Molekuliarnaia biologiia. 1993 Nov-Dec;27(6):1261-75