Pradimicins FS and FB, new pradimicin analogs: directed production, structures and biological activities.

K Saitoh, K Suzuki, M Hirano, T Furumai, T Oki

Bristol-Myers Squibb Research Institute, Tokyo, Japan.

The Journal of antibiotics 1993 Mar

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Exogenous addition of D-serine to Actinomadura spinosa AA0851 resulted in directed production of pradimicin FS, a new D-serine analog of pradimicin S, together with pradimicin FB. Pradimicin FS was produced in higher yields by derivation of ferrous sulfate-resistant strains from strain AA0851. Pradimicin FB, a minor product, was identified as deglucosylpradimicin FL. Pradimicin FS was equivalent to pradimicin S in syncytium formation inhibition activity and in vitro and in vivo antifungal activities.

Citation

K Saitoh, K Suzuki, M Hirano, T Furumai, T Oki. Pradimicins FS and FB, new pradimicin analogs: directed production, structures and biological activities. The Journal of antibiotics. 1993 Mar;46(3):398-405